Once Koch established the methods to grow pure cultures of bacteria like tuberculosis and anthrax, he demonstrated for the first time that microbes can cause diseases, a feat that earned him the 1905 Nobel Prize in Physiology or Medicine.
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Impact, in this context, is not a feel-good narrative; it’s a measurable one, even if more qualitatively than quantitatively in some cases. For me, it’s about which healthspan outcome is being targeted, for whom and why? How will progress be measured with replicable methods? What would count as failure? What tradeoffs are acceptable, and which ones are not? When founders and investors are aligned on these questions, capital becomes a tool for building evidence rather than amplifying narrative.